ZHONG Wenwan
Title: Associate Director
Affiliation:
Email: wenwanz@ustc.edu.cn
Research Field

1.Y. Sun, F. Xu, H. Liang, X. Fan, G. Wan, W. Zhong,*, Jun Jiang,* X. Li,*, & L. Chen*. MOSES: combining automated ontology construction with a multi-agent system for explainable chemical knowledge reasoning. AI for Science, 2026, 2, 015001. DOI 10.1088/3050-287X/ae3127.

2.Z. Li, M. Guo, W. Zhong*. Multiplex Detection of Biomarkers Empowered by Nanomaterials. Precision Chemistry, 2025, 3, 297-318.

3.J. Chen, P. Fasihianifard, R. Lian, L. Gibson-Elias, J. Moreno Jr., C.-E. A. Chang, W. Zhong*, and R. J. Hooley*. Supramolecular Host:Guest Arrays Site-Selectively Recognize Peptide Phosphorylation and Kinase Activity. Journal of American Chemical Society, 2025, 147, 1, 841–850. DOI:10.1021/jacs.4c13757.

4.Z. Li, K. Guo, Z. Gao, J. Chen, Z. Ye, S. E. Wang, Y. Yin, W. Zhong*. Colocalization of Protein and microRNA Markers Reveals Unique Extracellular Vesicle Sub-Populations for Early Cancer Detection. Science Advances, 2024, 10, eadh8689. 

5.R. Coreas, Z. Li, W. Zhong*. Low Dose Exposure of WS2 Nanosheets Induces Differential Apoptosis in Lung Epithelial Cells. Environmental Science & Technology, 2023, 57, 14493–14501.

6.W. Zhong, R. J. Hooley. Combining Excellent Selectivity with Broad Target Scope: Biosensing with Arrayed Deep Cavitand Hosts. Accounts of Chemical Research, 2022, 55, 7, 1035–1046.

7.J. Chen, B. L. Hickey, L. Wang, J. Lee, A. D. Gill, A. Favero, R. Pinalli, E. Dalcanale, R. J. Hooley* and W. Zhong*. Selective discrimination and classification of G-quadruplex structures with a host–guest sensing array. Nature Chemistry, 2021, 13(5):488-495.

8.L. Wang, J. Lee, L. Gao, J. Yin, Y. Duan, L. A. Jimenez, G. B. Adkins, W. Ren, L. Li, J. Fang, Y. Wang, J. Song*, W. Zhong*. A DNA aptamer for binding and inhibition of DNA methyltransferase 1. Nucleic Acids Research, 2019, 47, 11527-11537.

9.W. Shen, K. Guo, G. B. Adkins, Q. Jiang, Y. Liu, S. Sedano, Y. Duan, W. Yan, S. E. Wang, K. Bergersen, D. Worth, E. H. Wilson, W. Zhong*. A Single Extracellular Vesicle (EV) Flow Cytometry Approach to Reveal EV Heterogeneity. Angewandte Chemie, International Edition, 2018, 57, 15675-15680.


Representative Publications

1.Y. Sun, F. Xu, H. Liang, X. Fan, G. Wan, W. Zhong,*, Jun Jiang,* X. Li,*, & L. Chen*. MOSES: combining automated ontology construction with a multi-agent system for explainable chemical knowledge reasoning. AI for Science, 2026, 2, 015001. DOI 10.1088/3050-287X/ae3127.

2.Z. Li, M. Guo, W. Zhong*. Multiplex Detection of Biomarkers Empowered by Nanomaterials. Precision Chemistry, 2025, 3, 297-318.

3.J. Chen, P. Fasihianifard, R. Lian, L. Gibson-Elias, J. Moreno Jr., C.-E. A. Chang, W. Zhong*, and R. J. Hooley*. Supramolecular Host:Guest Arrays Site-Selectively Recognize Peptide Phosphorylation and Kinase Activity. Journal of American Chemical Society, 2025, 147, 1, 841–850. DOI:10.1021/jacs.4c13757.

4.Z. Li, K. Guo, Z. Gao, J. Chen, Z. Ye, S. E. Wang, Y. Yin, W. Zhong*. Colocalization of Protein and microRNA Markers Reveals Unique Extracellular Vesicle Sub-Populations for Early Cancer Detection. Science Advances, 2024, 10, eadh8689. 

5.R. Coreas, Z. Li, W. Zhong*. Low Dose Exposure of WS2 Nanosheets Induces Differential Apoptosis in Lung Epithelial Cells. Environmental Science & Technology, 2023, 57, 14493–14501.

6.W. Zhong, R. J. Hooley. Combining Excellent Selectivity with Broad Target Scope: Biosensing with Arrayed Deep Cavitand Hosts. Accounts of Chemical Research, 2022, 55, 7, 1035–1046.

7.J. Chen, B. L. Hickey, L. Wang, J. Lee, A. D. Gill, A. Favero, R. Pinalli, E. Dalcanale, R. J. Hooley* and W. Zhong*. Selective discrimination and classification of G-quadruplex structures with a host–guest sensing array. Nature Chemistry, 2021, 13(5):488-495.

8.L. Wang, J. Lee, L. Gao, J. Yin, Y. Duan, L. A. Jimenez, G. B. Adkins, W. Ren, L. Li, J. Fang, Y. Wang, J. Song*, W. Zhong*. A DNA aptamer for binding and inhibition of DNA methyltransferase 1. Nucleic Acids Research, 2019, 47, 11527-11537.

9.W. Shen, K. Guo, G. B. Adkins, Q. Jiang, Y. Liu, S. Sedano, Y. Duan, W. Yan, S. E. Wang, K. Bergersen, D. Worth, E. H. Wilson, W. Zhong*. A Single Extracellular Vesicle (EV) Flow Cytometry Approach to Reveal EV Heterogeneity. Angewandte Chemie, International Edition, 2018, 57, 15675-15680.